The Interplay between the Renin Angiotensin System and Pacing Postconditioning Induced Cardiac Protection.

Autor: Fawzi Babiker, Aishah Al-Jarallah, Shaji Joseph
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: PLoS ONE, Vol 11, Iss 11, p e0165777 (2016)
Druh dokumentu: article
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0165777
Popis: Accumulating evidence suggests a cardioprotective role of pacing postconditioning (PPC) maneuvers in animal models and more recently in humans. The procedure however remains to be optimized and its interaction with physiological systems remains to be further explored. The renin angiotensin system (RAS) plays a dual role in ischemia/reperfusion (I/R) injury. The interaction between RAS and PPC induced cardiac protection is however not clearly understood. We have recently demonstrated that angiotensin (1-7) via Mas receptor played a significant role in PPC mediated cardiac protection against I/R injury.The objective of this study was to investigate the role of angiotensin converting enzyme (ACE)-chymase-angiotensin II (Ang II)-angiotensin receptor 1 (AT1) axes of RAS in PPC mediated cardiac protection.Isolated rat hearts were subjected to I/R (control) or PPC in the presence or absence of Ang II, chymostatin (inhibitor of locally produced Ang II), ACE blocker (captopril) or AT1 antagonist (irbesartan). Hemodynamics data was computed digitally and infarct size was determined histologically using TTC staining and biochemically by measuring creatine kinase (CK) and lactate dehydrogenase levels.Cardiac hemodynamics were significantly (P
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