Direct evidence of VEGF-mediated neuroregulation and afferent explanation of blood pressure dysregulation during angiogenic therapy

Autor: Feng Yan, Li Ying, Yang Xinling, Han Limin, Wang Luning, Gao Shan, Yin Ruixue, Wang Xue, Li Jiayang, Liu Meiming, Li Baiyan
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Frigid Zone Medicine, Vol 1, Iss 2, Pp 119-126 (2021)
Druh dokumentu: article
ISSN: 2719-8073
DOI: 10.2478/fzm-2021-0015
Popis: Oncocardiology is increasingly hot research field/topic in the clinical management of cancer with anti-angiogenic therapy of vascular endothelial growth factor (VEGF) that may cause cardiovascular toxicity, such as hypertension via vascular dysfunction and attenuation of eNOS/NO signaling in the baroreflex afferent pathway. The aim of the current study was to evaluate the potential roles of VEGF/VEGF receptors (VEGFRs) expressed in the baroreflex afferent pathway in autonomic control of blood pressure (BP) regulation.
Databáze: Directory of Open Access Journals