Usefulness of serotoninergic challenge with oral citalopram
| Autor: | Paulo Mattos, Vanessa A Franco, François Noel, Daniel Segenreich, José Carlos Gonçalves |
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| Jazyk: | English<br />Portuguese |
| Rok vydání: | 2006 |
| Předmět: | |
| Zdroj: | Brazilian Journal of Psychiatry, Vol 28, Iss 3, Pp 203-205 (2006) |
| Druh dokumentu: | article |
| ISSN: | 1809-452X 1516-4446 |
| DOI: | 10.1590/S1516-44462006000300011 |
| Popis: | OBJECTIVE: Challenge tests designed to evaluate serotoninergic pathways have widely used intravenous citalopram. Oral citalopram has also been used, but unsatisfactory results were obtained with a dose of 20 mg. The objective of this study was to determine whether a higher oral dose would reproduce similar to those described for intravenous administration. To that end, we evaluated cortisol, growth hormone and prolactin levels. METHOD: Eight healthy male volunteers were evaluated in a randomized crossover challenge test with 40 mg of oral citalopram or placebo. RESULTS: Cortisol levels increased at 2-4h after the oral citalopram intake, with a small amplitude peak occurring in two-thirds of the subjects. Levels of prolactin and growth hormone remained unchanged throughout the study. CONCLUSION: The use of oral citalopram might present an alternative in serotoninergic challenge tests, but higher doses are required. |
| Databáze: | Directory of Open Access Journals |
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