Effects of MAP4K inhibition on neurite outgrowth

Autor: Di Ja Lasham, Reza K. Arta, Abdul Fuad Hadi, Jun Egawa, Vance P. Lemmon, Toshiyuki Takasugi, Michihiro Igarashi, Toshiyuki Someya
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Molecular Brain, Vol 16, Iss 1, Pp 1-7 (2023)
Druh dokumentu: article
ISSN: 1756-6606
74222724
DOI: 10.1186/s13041-023-01066-2
Popis: Abstract Protein kinases are responsible for protein phosphorylation and are involved in important intracellular signal transduction pathways in various cells, including neurons; however, a considerable number of poorly characterized kinases may be involved in neuronal development. Here, we considered mitogen-activated protein kinase kinase kinase kinases (MAP4Ks), related to as candidate regulators of neurite outgrowth and synaptogenesis, by examining the effects of a selective MAP4K inhibitor PF06260933. PF06260933 treatments of the cultured neurons reduced neurite lengths, not the number of synapses, and phosphorylation of GAP43 and JNK, relative to the control. These results suggest that MAP4Ks are physiologically involved in normal neuronal development and that the resultant impaired neurite outgrowth by diminished MAP4Ks’ activity, is related to psychiatric disorders.
Databáze: Directory of Open Access Journals
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