New Antimicrobial Bromotyrosine Analogues from the Sponge Pseudoceratina purpurea and Its Predator Tylodina corticalis

Autor: Michael P. Gotsbacher, Peter Karuso
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: Marine Drugs, Vol 13, Iss 3, Pp 1389-1409 (2015)
Druh dokumentu: article
ISSN: 1660-3397
DOI: 10.3390/md13031389
Popis: Bioassay-guided fractionation of extracts from temperate Australian collections of the marine sponge Pseudoceratina purpurea resulted in the isolation and characterisation of two new and six known bromotyrosine-derived alkaloids with antibiotic activity. Surprisingly, a single specimen of the mollusc Tylodina corticalis, which was collected while feeding on P. purpurea, contained only a few of the compounds found in the sponge suggesting selective accumulation and chemical modification of sponge metabolites.
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