Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways

Autor: Benedikt M. Mortzfeld, Jan Taubenheim, Alexander V. Klimovich, Sebastian Fraune, Philip Rosenstiel, Thomas C. G. Bosch
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-019-11136-6
Popis: Animals can adapt their body size to changing environments (e.g., temperature) but the underlying molecular mechanisms are unknown. Here, the authors show that temperature and the genetic factors insulin-like peptide receptor and FoxO determine size in Hydra via the conserved pathways (Wnt/TGF-β).
Databáze: Directory of Open Access Journals