| Autor: |
Dimov Peter K., Marinov Blagoi I., Ilchev Ilcho S., Taralov Zdravko Z., Kostianev Stefan S. |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Folia Medica, Vol 57, Iss 3-4, Pp 230-234 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
1314-2143 |
| DOI: |
10.1515/folmed-2015-0043 |
| Popis: |
Introduction: Exogenous hypoxia increases ventilation and contracts the pulmonary vessels. Whether those factors change the values of nitric oxide in exhaled air has not yet been evaluated. Objective: To examine the effect of exogenous normobaric hypoxia on the values of the fraction of nitric oxide in exhaled breath (FeNO). Subjects аnd Methods: Twenty healthy non-smoker males at mean age of 25.4 (SD = 3.7) were tested. The basal FeNO values were compared with those at 7 min. and 15 min. after introducing into the hypoxic environment (hypoxic tent), imitating atmospheric air with oxygen concentration corresponding to 3200 m above sea level. Exhaled breath temperature was measured at baseline and at 10-12 min. of the hypoxic exposition. Heart rate and oxygen saturation were registered by pulse-oximetry. Results: All the subjects had FeNO values in the reference range. The mean baseline value was 14.0 ± 3.2 ppb, and in hypoxic conditions - 15.5 ± 3.8 ppb (7 min.) and 15.3 ± 3.6 ppb (15 min.), respectively, as the elevation is statistically significant (p = 0.011 and p = 0.008). The values of exhaled breath temperature were 33.79 ± 1.55°С and 33.87 ± 1.83°С (p = 0.70) at baseline and in hypoxic conditions, respectively. Baseline oxygen saturation in all subjects was higher than that, measured in hypoxia (96.93 ± 1.29% vs. 94.27 ± 2.53%; p < 0.001). Conclusions: Exogenous hypoxia leads to an increase of FeNO values, but does not affect the exhaled breath temperature. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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