Neutralizing and interfering human antibodies define the structural and mechanistic basis for antigenic diversion

Autor: Palak N. Patel, Thayne H. Dickey, Christine S. Hopp, Ababacar Diouf, Wai Kwan Tang, Carole A. Long, Kazutoyo Miura, Peter D. Crompton, Niraj H. Tolia
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-33336-3
Popis: The Plasmodium falciparum Merozoite Surface Protein 1 (MSP-1) is a prime vaccine candidate for malaria. Here, the authors structurally and functionally characterise a panel of naturally acquired MSP-1 specific antibodies to identify one with potent broadly neutralising activity and better understand immune evasion mechanisms.
Databáze: Directory of Open Access Journals