Identification of the Tembusu Virus in Mosquitoes in Northern Thailand

Autor: Rodolphe Hamel, Ronald Enrique Morales Vargas, Dora Murielle Rajonhson, Atsushi Yamanaka, Jiraporn Jaroenpool, Sineewanlaya Wichit, Dorothée Missé, Anamika Kritiyakan, Kittipong Chaisiri, Serge Morand, Julien Pompon
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Viruses, Vol 15, Iss 7, p 1447 (2023)
Druh dokumentu: article
ISSN: 1999-4915
DOI: 10.3390/v15071447
Popis: Among emerging zoonotic pathogens, mosquito-borne viruses (MBVs) circulate between vertebrate animals and mosquitoes and represent a serious threat to humans via spillover from enzootic cycles to the human community. Active surveillance of MBVs in their vectors is therefore essential to better understand and prevent spillover and emergence, especially at the human–animal interface. In this study, we assessed the presence of MBVs using molecular and phylogenetic methods in mosquitoes collected along an ecological gradient ranging from rural urbanized areas to highland forest areas in northern Thailand. We have detected the presence of insect specific flaviviruses in our samples, and the presence of the emerging zoonotic Tembusu virus (TMUV). Reported for the first time in 1955 in Malaysia, TMUV remained for a long time in the shadow of other flaviviruses such as dengue virus or the Japanese encephalitis virus. In this study, we identified two new TMUV strains belonging to cluster 3, which seems to be endemic in rural areas of Thailand and highlighted the genetic specificities of this Thai cluster. Our results show the active circulation of this emerging flavivirus in Thailand and the need for continuous investigation on this poorly known but threatening virus in Asia.
Databáze: Directory of Open Access Journals
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