The effectiveness of gabapentin and gabapentin/montelukast combination compared with dextromethorphan in the improvement of COVID‐19‐ related cough: A randomized, controlled clinical trial

Autor: Rasool Soltani, Sara Nasirharandi, Farzin Khorvash, Maryam Nasirian, Kian Dolatshahi, Atousa Hakamifard
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: The Clinical Respiratory Journal, Vol 16, Iss 9, Pp 604-610 (2022)
Druh dokumentu: article
ISSN: 1752-699X
1752-6981
DOI: 10.1111/crj.13529
Popis: Abstract Introduction Cough is one of the most common presenting symptoms of COVID‐19, which can persist for weeks or months. Objective The goal of this study was to evaluate the effectiveness of gabapentin (GBT) alone and in combination with montelukast (MTL) for improving cough. Methods In this open‐label randomized controlled clinical trial, eligible cases were patients hospitalized with moderate to severe COVID‐19 who had cough with a Breathlessness, Cough, and Sputum Scale (BCSS) score of at least 2 based on its cough subscale. The participants were randomly assigned to three groups including two experimental groups and one control group. The first and second experimental groups received GBT and GBT/MTL, respectively, whereas the control group received dextromethorphan (DXM). Treatment duration was 5 days in all groups. Before and after the interventions, the severity of cough was evaluated using BCSS scale and Visual Analog Scale (VAS). Results A total of 180 patients were included; GPT, GPT/MTL, and DXM consisted of 76, 51, and 53 patients, respectively. There was no significant difference between the three groups in terms of age, gender, and comorbidities (P > 0.05). Regarding BCSS and VAS scores, there was significant reduction from the baseline values in all groups (P
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