Usefulness of CRP as a prognostic marker in the clinical course of Covid-19 infection during the three waves: A retrospective study

Autor: Shailaja Alapaty, Suhas Dhulipala, Jyothi A Natikar, H Ajit, Mangala Sirsikar, Umalakshmi Annavarapu, Deepthi Mahendrakar
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Medical Journal of Dr. D.Y. Patil Vidyapeeth, Vol 15, Iss 8, Pp 253-258 (2022)
Druh dokumentu: article
ISSN: 2589-8302
2589-8310
DOI: 10.4103/mjdrdypu.mjdrdypu_437_22
Popis: Introduction: COVID-19 is an emerging public health problem. It comprises of a large virus family causing varying infection ranging from common cold to more severe infection. Classification of cases into mid, moderate, severe helps for effective management and treatment. CRP is a highly sensitive biomarker for inflammation, tissue damage. Materials and Methods: A retrospective cohort study was done during March 2020 to Feb 2021. Total 2,239 patients were included in the study. CRP levels were measured in hospitalized patients on the day of admission. Statistical Analysis: Continuous variables are presented as Mean ± standard deviation and Median (Q1, Q3). Qualitative variables are presented as frequency and percentage. The continuous variables were compared using independent t test, one-way analysis of variance or Kruskal–Wallis test. Receiver operating characteristic curves (ROC) were constructed to identify the predictability and best cut-offs of variables to differentiate moderate illness from severe–critical illness, severe illness from critical illness, and survivors from non-survivors. A two-tailed P value 1.85. Conclusion: CRP is a simple test that helps in initiating primary care. It indicates the severity of disease in COVID-19 infection. CRP can be used as a marker for disease progression and also indicates the severity of lung involvement.
Databáze: Directory of Open Access Journals
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