| Autor: |
Ti Huang, Xu Yan, Xiaoguang Yan, Fei Huang, Jie Li, Juncai Xiao, Yi Li |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Journal of Traditional Chinese Medical Sciences, Vol 4, Iss 2, Pp 149-157 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2095-7548 |
| DOI: |
10.1016/j.jtcms.2017.05.005 |
| Popis: |
Objective: To investigate the effect of decocted Coptis chinensis Franch. (Huanglian Jianji, 黄连煎剂, HLJJ) and berberine on the gut microbiota of the rats with metabolic syndrome (MS) induced by high-fat diet (HFD). Methods: Sixty Sprague Dawley rats were randomly divided into normal diet (ND) group (n = 15) and HFD group (n = 45). After 8 weeks of feeding, the HFD group was further divided into three groups: a group provided with a combination of HLJJ and HFD for 4 weeks, a group provided with a combination of berberine and HFD for 4 weeks, and a group supplied only with HFD for 4 consecutive weeks. Epididymal fat weight, serum high-density lipoproteincholesterol-C (HDL-C), low-density lipoproteincholesterol-C (LDL-C) and irisin levels were measured. In addition, the V3-V4 region of the cecum microbiota 16S rRNA gene amplicon was sequenced on the Illumina MiSeq platform. Results: MS was successfully induced in the rats with HFD for 8 weeks. After 12 weeks, serum irisin levels in the HFD + berberine group were significantly increased compared with those in the HFD group (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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