The possible role of Cytochrome c and programmed cell death protein 4 (PDCD4) on pathogenesis of hepatocellular carcinoma
| Autor: | Mei Afify, Refaat R. Kamel, Yasser A. Elhosary, Abdelfattah E. Hegazy, Hoda H. Fahim, Wafaa M. Ezzat |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Journal of Genetic Engineering and Biotechnology, Vol 13, Iss 2, Pp 157-163 (2015) |
| Druh dokumentu: | article |
| ISSN: | 1687-157X 15370151 |
| DOI: | 10.1016/j.jgeb.2015.10.002 |
| Popis: | Background: Hepatocellular carcinoma (HCC) is regarded as one of the most common malignancies and among the leading causes of cancer death in the whole world. Apoptosis is a fundamental process controlling cell death and plays a critical role in normal development of multicellular organisms. When abnormalities occur in apoptosis, a variety of diseases are caused, including cancer. The aim of the current study was to determine the serum expression of Cytochrome c and PDCD4 among patients with hepatocellular carcinoma and chronic hepatitis. Patients and methods: A total of 40 serum and tissue samples (17 samples from chronic hepatitis and 23 samples from HCC patients) were collected. Apoptotic markers in serum were carried out using the quantitative sandwich enzyme immunoassay technique. Results: We found that serum levels of PCDC4 and Cytochrome c were increased in patients with HCC when compared to chronic hepatitis patients. They were also increased in patients with chronic hepatitis when compared to controls (p |
| Databáze: | Directory of Open Access Journals |
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