| Autor: |
Yahya Altınkaynak, Asım Örem, Buket Akcan Altınkaynak, Birgül Kural, Fulya Balaban Yücesan, Cihan Örem |
| Jazyk: |
English<br />Turkish |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Acta Medica Alanya, Vol 3, Iss 1, Pp 3-11 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2587-0319 |
| DOI: |
10.30565/medalanya.455820 |
| Popis: |
Aim: Paraoxonase-1 (PON1) whic is present in HDL structure, is an enzyme that decreases the oxidative stress in atherosclerotic lesions by preventing the HDL and LDL against to ox-idation. Thu study aims to determine the paraoxonase, arylesterase and lactonease activities of PON1 enzyme, taking into account the response of healthy subjects to the oral triglyceride tolerance test (OTTT). Material and Method: Study group included 96 healthy subjects (45 female and 51 male with age range of 18-55 years). Study group was divided into three groups according to the area under curve (AUC) values calculated by using triglyceride levels at the fasting state and at 2nd, 4th and 6th hours after the high fat diet (OTTT). PON1 enzyme activity levels were determined by spectrofotometric methods. PON1 enzyme activities and other parameters in lower OTTT response group were compared to that of the upper group. Results: Atherogenic lipid profile, increased total cholesterol and LDL-C and decreased HDL-C levels, was observed in subjects with the upper group men when compared to the lower group. PON1 lactonase activity was significantly lower in men than that of women (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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