| Autor: |
Alexandra Avgustinova, Marjan Iravani, David Robertson, Antony Fearns, Qiong Gao, Pamela Klingbeil, Andrew M. Hanby, Valerie Speirs, Erik Sahai, Fernando Calvo, Clare M. Isacke |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/ncomms10305 |
| Popis: |
How cancer-associated fibroblasts become activated to support metastasis is not well understood. Here, Avgustinova et al. show that tumour cell-derived Wnt7a activates TGFβ signaling in fibroblasts, inducing them to remodel the microenvironment to the state, which promotes tumour invasiveness and metastasis. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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