Comparative assessment of hepatoprotective effects of various liposome formulations in experimental venous congestion-induced chronic liver insufficiency
| Autor: | R. A. Mukhamadiyarov, N. L. Vorontsova, V. V. Borisov, Yu. A. Kudryavtseva, I. Yu. Juravleva |
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| Jazyk: | English<br />Russian |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Бюллетень сибирской медицины, Vol 11, Iss 4, Pp 130-135 (2012) |
| Druh dokumentu: | article |
| ISSN: | 1682-0363 1819-3684 |
| DOI: | 10.20538/1682-0363-2012-4-130-135 |
| Popis: | The aim of the study was to evaluate the efficacy of lecithin/cholesterol liposomes in the therapy of experimental venous congestion-induced chronic liver insufficiency. The effects of the empty liposomes, ATP and phosphocreatine-containing liposomes and alpha-tocopherol and superoxide dismutase-containing liposomes were studied. It was found that liposomal drugs have a hepatoprotective effect, i.e. they decrease blood enzyme activity (cytolysis markers), reduce oxidative stress and preserve histologic integrity of the liver. |
| Databáze: | Directory of Open Access Journals |
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