Comparison of polyethylene glycol 3350 electrolyte solution and lactulose in patients with overt hepatic encephalopathy: A retrospective study from a tertiary care hospital

Autor: Beg MA, Mushtaq M, Andrabi SS, Mir IS, Gulzar GM, Zargar SA
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Medical and Scientific Research, Vol 10, Iss 4, Pp 206-211 (2022)
Druh dokumentu: article
ISSN: 2321-1326
2394-112X
DOI: 10.17727/JMSR.2022/10-38
Popis: Background: Hepatic encephalopathy (HE) is a brain dysfunction caused by liver failure and/or porto-systemic shunt and it manifests as a wide spectrum of neurological or psychiatric abnormalities. The aim of the study was to evaluate if polyethylene glycol (PEG) is more effective than lactulose in resolution of encephalopathy and determine if it decreases the hospital stay. Material and methods: Retrospectively from hospital records we selected 80 patients with hepatic encephalopathy (HE) due to underlying cirrhosis of liver. Forty (40) patients were taken from the group who were treated with lactulose and based on age matching (± 2 years) and encephalopathy grade matching (±1 grade) 40 patients were selected from the group who were treated with PEG. Grading of HE was determined by using hepatic encephalopathy scoring algorithm (HESA) and West Haven (WH) criteria. Resolution of HE was defined as improvement in HESA/West Haven score to grade 0, patient discharge or 2 consecutive days when HESA grade remained at 1 after an initial improvement of at least 1 full grade. Results: The mean age of PEG group was similar to lactulose group (58.2 ± 10.11 vs 58.70 ± 9.54 years; p = 0.829) with a male predominance in both groups. All patients were of Child Turcot Pugh (CTP) class C with a mean MELD score of 18.7±5.42 vs 18.9±4.75 in PEG group and lactulose group respectively (p = 0.827). The time taken for complete resolution of HE was also lesser in PEG group compared to lactulose group with a significant p value of
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