Microchip imaging cytometer: making healthcare available, accessible, and affordable

Autor: Xilong Yuan, Todd Darcie, Ziyin Wei, J Stewart Aitchison
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Opto-Electronic Advances, Vol 5, Iss 11, Pp 1-15 (2022)
Druh dokumentu: article
ISSN: 2096-4579
DOI: 10.29026/oea.2022.210130
Popis: The Microchip Imaging Cytometer (MIC) is a class of integrated point-of-care detection systems based on the combination of optical microscopy and flow cytometry. MIC devices have the attributes of portability, cost-effectiveness, and adaptability while providing quantitative measurements to meet the needs of laboratory testing in a variety of healthcare settings. Based on the use of microfluidic chips, MIC requires less sample and can complete sample preparation automatically. Therefore, they can provide quantitative testing results simply using a finger prick specimen. The decreased reagent consumption and reduced form factor also help improve the accessibility and affordability of healthcare services in remote and resource-limited settings. In this article, we review recent developments of the Microchip Imaging Cytometer from the following aspects: clinical applications, microfluidic chip integration, imaging optics, and image acquisition. Following, we provide an outlook of the field and remark on promising technologies that may enable significant progress in the near future.
Databáze: Directory of Open Access Journals