| Autor: |
Nicola Martinelli, Anna Maria Rigoni, Sergio De Marchi, Nicola Osti, Martino Donini, Martina Montagnana, Annalisa Castagna, Patrizia Pattini, Silvia Udali, Lucia De Franceschi, Elisa Tinazzi, Filippo Mazzi, Sara Moruzzi, Giuseppe Argentino, Lorenzo Delfino, Giulia Sartori, Anna Maria Azzini, Evelina Tacconelli, Patrick Van Dreden, Giuseppe Lippi, Domenico Girelli, Oliviero Olivieri, Simonetta Friso, Francesca Pizzolo |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Diagnostics, Vol 12, Iss 11, p 2792 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2075-4418 |
| DOI: |
10.3390/diagnostics12112792 |
| Popis: |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causal agent of coronavirus disease 2019 (COVID-19), in which coagulation abnormalities and endothelial dysfunction play a key pathogenic role. Tissue factor (TF) expression is triggered by endothelial dysfunction. Activated factor VII-antithrombin (FVIIa-AT) complex reflects indirectly FVIIa-TF interaction and has been proposed as a potential biomarker of prothrombotic diathesis. FVIIa-AT plasma concentration was measured in 40 patients (30 males and 10 females; 64.8 ± 12.3 years) admitted with SARS-CoV-2 pneumonia during the first pandemic wave in Italy. Two sex- and age-matched cohorts without COVID-19, with or without signs of systemic inflammation, were used to compare FVIIa-AT data. The FVIIa-AT plasma levels in COVID-19 patients were higher than those in non-COVID-19 subjects, either with or without inflammation, while no difference was observed among non-COVID-19 subjects. The association between COVID-19 and FVIIa-AT levels remained significant after adjustment for sex, age, C-reactive protein, renal function, fibrinogen, prothrombin time and activated partial thromboplastin time. Our results indicate that SARS-CoV-2 infection, at least during the first pandemic wave, was characterized by high FVIIa-AT levels, which may suggest an enhanced FVIIa-TF interaction in COVID-19, potentially consistent with SARS-CoV-2-induced endotheliopathy. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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