| Autor: |
Kirk C. Wilhelmsen, Pierre-François D’Haese, Marc W. Haut, Gary D. Marano, Rashi I. Mehta, Xiaofei Wang, Melanie Ward, Mark Miller, Umer Najib, R. Osvaldo Navia, Cierra M. Keith, Ali Rezai |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Neuroimage: Reports, Vol 4, Iss 2, Pp 100203- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2666-9560 |
| DOI: |
10.1016/j.ynirp.2024.100203 |
| Popis: |
This case report investigates the potential use of metabolism as a sensitive biomarker in monitoring the effectiveness of anti-amyloid therapy in a patient with mild cognitive impairment due to early Alzheimer's disease. The study centers around a 74-year-old male patient treated with aducanumab, a monoclonal antibody developed for anti-amyloid therapy. Alongside an expected decline in cerebral amyloid monitored using PET amyloid tracers, we observed significant improvements in the patient's brain metabolic activity, measured via 18-fluorodeoxyglucose positron emission tomography (FDG PET). Despite limitations posed by the single-patient case study, the findings invite further research and consider the utilization of FDG PET as a surrogate for clinically meaningful changes in the treatment of early Alzheimer's disease. These findings suggest the potential for more personalized and effective therapeutic interventions. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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