High-dose benznidazole in a 62-year-old Bolivian kidney transplant recipient with Chagas central nervous system involvement

Autor: M. Montero, M. Mir, E. Sulleiro, J.L. Avalos Esquivel, E. García López, D. Molina-Morant, I. López Montesinos, L. Sorlí, G. Veliz Espinosa, E. Mounteis Oliva, M. Crespo, I. Monge, J.P. Horcajada, S. Grau, J. Pascual
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: International Journal of Infectious Diseases, Vol 78, Iss , Pp 103-106 (2019)
Druh dokumentu: article
ISSN: 1201-9712
DOI: 10.1016/j.ijid.2018.10.014
Popis: There is little published data on benznidazole dosing, or levels in cerebrospinal fluid. In this report, we describe the clinical course of an immunosuppressed patient with Chagas central nervous system involvement. He was treated successfully with larger benznidazole doses than are recommended, in order to reach therapeutically effective concentrations in the brain. Keywords: Chagas disease, Kidney transplant recipient, Chagoma, Benznidazole dose, Benznidazole PK/PD
Databáze: Directory of Open Access Journals