| Autor: |
D. Flachs, J. Etzel, M. Mayer, F. Harbecke, S. Belle, T. Rickmeyer, C. Thielemann |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Biomedical Engineering Advances, Vol 4, Iss , Pp 100045- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2667-0992 |
| DOI: |
10.1016/j.bea.2022.100045 |
| Popis: |
In recent years, there has been an increasing interest in electrically conductive hydrogels for a wide range of biomedical applications, like tissue engineering or biosensors. In this study, we present a cost-effective conductive hydrogel based on alginate and graphene nanoplatelets for extrusion-based bioprinters. The hydrogel is prepared under ambient conditions avoiding high temperatures detrimental for cell culture environments. Investigation of the hydrogel revealed a conductivity of up to 7.5 S/cm, depending on the ratio of platelets. Furthermore, in vitro tests with human embyronic kidney cells - as an example cell type - showed good adhesion of the cells to the surface of the conductive hydrogel. Electrochemical measurements revealed a low electrode impedance which is desirable for the extracellular recording, but also low electrode capacitance, which is unfavorable for electrical stimulation purposes. Therefore, future experiments with the graphene nanoplatelets-based hydrogels will focus on electrodes for biosensors and extracellular recordings of neurons or cardiac myocytes. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
