Three New Ionone Glycosides from Rhododendron capitatum Maxim

Autor:	Jun-Ren Yang, Yue-Tong Zhu, Yi-Qin Zeng, Hong-Quan Li, Chun-Huan Li, Jin-Ming Gao
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Rhododendron capitatum sesquiterpenoids ionone glycosides anti-inflammatory activity Organic chemistry QD241-441
Zdroj:	Molecules, Vol 29, Iss 11, p 2462 (2024)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules29112462
Popis:	Six ionone glycosides (1–3 and 5–7), including three new ones, named capitsesqsides A−C (1–3), together with an eudesmane sesquiterpenoid glycoside (4) and three known triterpenoid saponins (8–10) were isolated from Rhododendron capitatum. The structures of these compounds were determined by extensive spectroscopic techniques (MS, UV, 1D-NMR, and 2D-NMR) and comparison with data reported in the literature. The absolute configurations were determined by comparison of the experimental and theoretically calculated ECD curves and LC-MS analyses after acid hydrolysis and derivatization. The anti-inflammatory activities of these compounds were evaluated in the LPS-induced RAW264.7 cells. Molecular docking demonstrated that 2 has a favorable affinity for NLRP3 and iNOS.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/c4da523f46204b389d48c09bccabbb22 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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