| Autor: |
Ava Soltani Hekmat, Kazem Javanmardi, Alireza Tavassoli, Yousof Gholampour |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Anatolian Journal of Cardiology, Vol 23, Iss 4, Pp 209-217 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2149-2263 |
| DOI: |
10.14744/AnatolJCardiol.2019.40072 |
| Popis: |
Objective: Isoproterenol (ISO)-induced heart failure is a standardized model for the study of beneficial effects of various drugs. Both apelin and angiotensin 1-7 have a cardiac protective effect. We assumed that co-therapy with apelin and angiotensin 1-7 (Ang (1-7)) may have synergistic cardioprotective effects against isoproterenol-induced heart failure. Methods The animals were randomly assigned to one of eight groups of seven animals in each group as follows: (1) control I (saline; IP injection) (1) control II (saline; via mini-osmotic pump) (3) ISO (5 mg/ kg; IP), (4) Apelin (20μg/ kg; IP), (5) Ang (1-7) (30 μg/kg/day; via mini-osmotic pump), (6) Apelin+ISO, (7) Ang (1-7)+ISO, (8) Apelin+Ang (1-7)+ISO. Rat myocardial injury was induced by intraperitoneal injection of 5mg/kg of ISO for ten days. Apelin and Ang (1-7) were administered 30 minutes before ISO injection. Results: A decrease in systolic blood pressure (SBP; p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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