Role of Real-World Data in Assessing Cardiac Toxicity After Lung Cancer Radiotherapy

Autor: Azadeh Abravan, Gareth Price, Kathryn Banfill, Tom Marchant, Matthew Craddock, Joe Wood, Marianne C. Aznar, Alan McWilliam, Marcel van Herk, Corinne Faivre-Finn
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Frontiers in Oncology, Vol 12 (2022)
Druh dokumentu: article
ISSN: 2234-943X
DOI: 10.3389/fonc.2022.934369
Popis: Radiation-induced heart disease (RIHD) is a recent concern in patients with lung cancer after being treated with radiotherapy. Most of information we have in the field of cardiac toxicity comes from studies utilizing real-world data (RWD) as randomized controlled trials (RCTs) are generally not practical in this field. This article is a narrative review of the literature using RWD to study RIHD in patients with lung cancer following radiotherapy, summarizing heart dosimetric factors associated with outcome, strength, and limitations of the RWD studies, and how RWD can be used to assess a change to cardiac dose constraints.
Databáze: Directory of Open Access Journals