The Role of Serum Cytokines in the Pathogenesis of Hepatic Osteodystrophy in Male Cirrhotic Patients
| Autor: | Ali Riza Soylu, Cengiz Tuglu, Ender Arikan, Tarkan Yetisyigit, Hakan Kunduracılar, Ibrahim Hakki Koker, Gulbin Unsal, Ahmet Huseyin Tezel, Hasan Umit, Sakir Berkarda |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Gastroenterology Research and Practice, Vol 2012 (2012) |
| Druh dokumentu: | article |
| ISSN: | 1687-6121 1687-630X |
| DOI: | 10.1155/2012/425079 |
| Popis: | Objective. In this study, we aimed to investigate the possible role of serum cytokines in the development of hepatic osteodystrophy. Matherial and Methods. 44 consecutive male cirrhotic patients (17 alcoholic, 20 hepatitis B, 7 hepatitis C), 15 age- and sex-matched chronic alcoholics without liver disease, and 17 age- and sex-matched healthy controls were included in the study during one year period. Bone mineral density was measured by dual X-ray absorptiometry in the lumbar vertebrate and femoral neck. Serum interleukin levels were measured by ELISA method. Results. Although osteopenia frequency between our cirrhotic patients was 20%, there was no difference in T-scores among the controls and other groups. Serum interleukin-1, interleukin-8, and tumor necrosis factor-alpha levels were not different between all groups. Serum interleukin-2 and interleukin-6 levels were higher in the cirrhotics than controls (P |
| Databáze: | Directory of Open Access Journals |
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