| Autor: |
Anusha Vittal, Mark Shapses, Bashar Sharma, Disha Sharma, Qian Sun, Maureen Sampson, Wilson Lee, Gil Ben Yakov, Yaron Rotman |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Hepatology Communications, Vol 5, Iss 4, Pp 589-597 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2471-254X |
| DOI: |
10.1002/hep4.1658 |
| Popis: |
The recently developed lipoprotein insulin resistance index (LP‐IR) incorporates lipoprotein particle numbers and sizes and is considered to reflect both hepatic and peripheral IR. As tissue IR is a strong component of nonalcoholic fatty liver disease (NAFLD) pathogenesis, we aimed to assess the degree by which LP‐IR associates with hepatic fat content. This was a single‐center retrospective analysis of patients with NAFLD. LP‐IR, the homeostasis model assessment of insulin resistance (HOMA‐IR), and adipose tissue IR (Adipo‐IR) were measured simultaneously. Liver fat content was estimated by FibroScan controlled attenuated parameter. Associations were assessed using Spearman’s correlation and multivariate linear regression. The study included 61 patients. LP‐IR was correlated with HOMA‐IR (ρ = 0.30; P = 0.02), typically thought to reflect hepatic IR, but not with Adipo‐IR (ρ = 0.15; P = 0.25). Liver fat content was significantly associated with Adipo‐IR (ρ = 0.48; P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
Plný text