| Autor: |
WU Dingjiang, ZHANG Xiufeng |
| Jazyk: |
čínština |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Jichu yixue yu linchuang, Vol 44, Iss 8, Pp 1165-1169 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1001-6325 |
| DOI: |
10.16352/j.issn.1001-6325.2024.08.1165 |
| Popis: |
Severe asthma is a chronic inflammatory disease that is not sensitive to glucocorticoid treatment. In the pathogenesis of severe asthma, T helper cell 17(Th17) and interleukin 17 (IL-17) play an important role, mainly by aggregating the infiltration of neutrophil to aggravate the severity of asthma. Methyl-CpG-binding protein 2 (MBD2) plays an important role in the differentiation of Th17 cells from naive CD4+T cells,positively regulate Th17 differentiation and IL-17 expression. MBD2 binds to the CpG islands in the promoter region of interferon regulatory factor 4 (IRF4), suppressor of cytokine signaling 3 (SOCS3), hypoxia-inducible factor-1α (HIF-1α) and misshapen like kinase 1(MINK1), which leads to methylation, regulates the differentiation of Th17 cells, and participates in the pathogenesis of severe asthma. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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