Amelioration of hyperglycemia by Rubus occidentalis (black raspberry) and increase in short-chain fatty acids producing bacteria

Autor: Heetae Lee, Jiyeon Kim, Jinho An, Sungwon Lee, Hyunseok Kong, Youngcheon Song, Hye Ran Choi, Su Jung Lee, Kyu Seo Chae, Ji Wung Kwon, Kyungjae Kim
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Journal of Functional Foods, Vol 54, Iss , Pp 433-439 (2019)
Druh dokumentu: article
ISSN: 1756-4646
DOI: 10.1016/j.jff.2019.01.045
Popis: Increasing evidence suggests that gut microbiota play an important role in metabolic disorders. Rubus occidentalis (RO) (black raspberry) has antioxidant and anti-inflammatory effects and improves metabolic disorders such as hypertension and insulin resistance. This study investigated the composition of gut microbiota in RO-treated mice using an aged mouse model of high-fat diet-induced obesity. RO significantly improved mouse glucose profiles, including serum glucose levels and intraperitoneal glucose tolerance test results. RO treatment caused significant increases in the relative abundance of various genera including Bacteroides, Butyricimonas, Mucispirillum, and Ruminococcus. Moreover, these increased genera correlated with the glucose profiles. Our findings suggest that the effect of RO on glucose control is associated with an increase in short-chain fatty acids producing bacteria.
Databáze: Directory of Open Access Journals