| Autor: |
Amy Song, Julie Y. Li, Samuel G. Cockey, Richard Shao, Hailing Zhang |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Case Reports in Hematology, Vol 2024 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2090-6579 |
| DOI: |
10.1155/2024/3267739 |
| Popis: |
Mantle cell lymphoma (MCL) is a mature B-cell lymphoma associated with cyclin D family rearrangements and typically expresses CD5 and cyclin D1. Epstein–Barr virus- (EBV-) positive MCL is rare, and the role of EBV infection and its transformation in MCL remains unclear. We present a case of CD5-negative classic MCL that progressed to an EBV + pleomorphic MCL six years after the initial diagnosis. Molecular studies confirmed the same clonal origin. To the best of our knowledge, the EBV-positive transformation of CD5-negative MCL into a pleomorphic variant has rarely been reported, and its recognition is important for the diagnosis and the management of patients with MCL. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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