Chronic marijuana usage by human pancreas donors is associated with impaired islet function

Autor: Meirigeng Qi, John S. Kaddis, Kuan-Tsen Chen, Jeffrey Rawson, Keiko Omori, Zhen Bouman Chen, Sangeeta Dhawan, Jeffrey S. Isenberg, Fouad Kandeel, Bart O. Roep, Ismail H. Al-Abdullah
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: PLoS ONE, Vol 16, Iss 10 (2021)
Druh dokumentu: article
ISSN: 1932-6203
Popis: We investigated the effect of chronic marijuana use, defined as 4 times weekly for more than 3 years, on human pancreatic islets. Pancreata from deceased donors who chronically used marijuana were compared to those from age, sex and ethnicity matched non-users. The islets from marijuana-users displayed reduced insulin secretion as compared to islets from non-users upon stimulation with high glucose (AUC, 3.41 ± 0.62 versus 5.14 ±0.47, p
Databáze: Directory of Open Access Journals
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