Analysis of the influence of glutathione S-transferase (GSTM1 and GSTT1) genes on the risk of essential hypertension

Autor:	Sanaa Nassereddine, Rachida Habbal, Yaya Kassogue, Ait Boujmia Oum Kaltoum, Korchi Farah, Haraka Majda, Abou Elfath Rhizlane, Sellama Nadifi, Hind Dehbi
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	glutathione s-transferase gstm1 gstt1 essential hypertension morocco Biology (General) QH301-705.5 Human anatomy QM1-695 Physiology QP1-981
Zdroj:	Annals of Human Biology, Vol 48, Iss 7-8, Pp 585-589 (2021)
Druh dokumentu:	article
ISSN:	0301-4460 1464-5033 03014460
DOI:	10.1080/03014460.2022.2039291
Popis:	Background Essential hypertension (EH) results from a complex interaction between environmental factors and an individual’s genetic background. Aim To assess the relationship between polymorphisms in GSTM1 and GSTT1 and the risk of EH. Subjects and methods A multiplex-PCR was used to identify the genotypic profiles of GSTM1 and GSTT1 in 160 patients and 210 controls. Results The frequency of GSTM1-null genotype was higher in patients younger than 61 years when compared to those over 61 years. Interestingly, GSTT1-null was significantly associated with the risk of EH (OR 4; 95% CI 2.6–6.3; p
Databáze:	Directory of Open Access Journals
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