Circulating biomarkers in malignant pleural mesothelioma

Autor: Giuseppe Viscardi, Davide Di Natale, Morena Fasano, Marta Brambilla, Riccardo Lobefaro, Alessandro De Toma, Giulia Galli
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Exploration of Targeted Anti-tumor Therapy, Vol 1, Iss 6, Pp 434-451 (2020)
Druh dokumentu: article
ISSN: 2692-3114
DOI: 10.37349/etat.2020.00028
Popis: Malignant pleural mesothelioma (MPM) is an aggressive tumor strictly connected to asbestos exposure. Prognosis is dismal as diagnosis commonly occurs in advanced stage. Radiological screenings have not proven to be effective and also pathological diagnosis may be challenging. In the era of precision oncology, validation of robust non-invasive biomarkers for screening of asbestos-exposed individuals, assessment of prognosis and prediction of response to treatments remains an important unmet clinical need. This review provides an overview on current understanding and possible applications of liquid biopsy in MPM, mostly focused on the utility as diagnostic and prognostic test.
Databáze: Directory of Open Access Journals