Targeting of the AKT/m-TOR Pathway: Biomarkers of Resistance to Cancer Therapy—— AKT/m-TOR Pathway and Resistance to Cancer Therapy
| Autor: | Liudmila V SPIRINA, Irina V KONDAKOVA, Natalia V TARASENKO, Elena M SLONIMSKAYA, Evgeny A USYNIN, Alexey K GORBUNOV, Zahar A YURMAZOV, Svetlana Yu CHIGEVSKAYA |
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| Jazyk: | čínština |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Chinese Journal of Lung Cancer, Vol 21, Iss 1, Pp 63-66 (2018) |
| Druh dokumentu: | article |
| ISSN: | 1009-3419 1999-6187 |
| DOI: | 10.3779/j.issn.1009-3419.2018.01.09 |
| Popis: | Resistance to cancer therapy continues to be a major limitation for the successful treatment of cancer. There are many published studies on therapy resistance in breast and prostate cancers; however, there are currently no data on molecular markers associated with resistance. The conflicting data were reported regarding the AKT/m-TOR signaling pathway components as markers predicting resistance. The AKT/m-TOR signaling pathway is involved in the development of many human cancers; its activation is related to cell proliferation, angiogenesis, apoptosis, as well as to therapy resistance. Molecular alterations in the AKT/m-TOR signaling pathway provide a platform to identify universal markers associated with the development of resistance to cancer therapy. |
| Databáze: | Directory of Open Access Journals |
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