Targeting of the AKT/m-TOR Pathway: Biomarkers of Resistance to Cancer Therapy—— AKT/m-TOR Pathway and Resistance to Cancer Therapy

Autor: Liudmila V SPIRINA, Irina V KONDAKOVA, Natalia V TARASENKO, Elena M SLONIMSKAYA, Evgeny A USYNIN, Alexey K GORBUNOV, Zahar A YURMAZOV, Svetlana Yu CHIGEVSKAYA
Jazyk: čínština
Rok vydání: 2018
Předmět:
Zdroj: Chinese Journal of Lung Cancer, Vol 21, Iss 1, Pp 63-66 (2018)
Druh dokumentu: article
ISSN: 1009-3419
1999-6187
DOI: 10.3779/j.issn.1009-3419.2018.01.09
Popis: Resistance to cancer therapy continues to be a major limitation for the successful treatment of cancer. There are many published studies on therapy resistance in breast and prostate cancers; however, there are currently no data on molecular markers associated with resistance. The conflicting data were reported regarding the AKT/m-TOR signaling pathway components as markers predicting resistance. The AKT/m-TOR signaling pathway is involved in the development of many human cancers; its activation is related to cell proliferation, angiogenesis, apoptosis, as well as to therapy resistance. Molecular alterations in the AKT/m-TOR signaling pathway provide a platform to identify universal markers associated with the development of resistance to cancer therapy.
Databáze: Directory of Open Access Journals