| Autor: |
Michael J. LaMonte, Robert J. Genco, Michael J. Buck, Daniel I. McSkimming, Lu Li, Kathleen M. Hovey, Christopher A. Andrews, Wei Zheng, Yijun Sun, Amy E. Millen, Maria Tsompana, Hailey R. Banack, Jean Wactawski-Wende |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
BMC Oral Health, Vol 19, Iss 1, Pp 1-44 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1472-6831 |
| DOI: |
10.1186/s12903-019-0906-2 |
| Popis: |
Abstract Background The extent to which the composition and diversity of the oral microbiome varies with age is not clearly understood. Methods The 16S rRNA gene of subgingival plaque in 1219 women, aged 53–81 years, was sequenced and its taxonomy annotated against the Human Oral Microbiome Database (v.14.5). Composition of the subgingival microbiome was described in terms of centered log(2)-ratio (CLR) transformed OTU values, relative abundance, and prevalence. Correlations between microbiota abundance and age were evelauted using Pearson Product Moment correlations. P-values were corrected for multiple testing using the Bonferroni method. Results Of the 267 species identified overall, Veillonella dispar was the most abundant bacteria when described by CLR OTU (mean 8.3) or relative abundance (mean 8.9%); whereas Streptococcus oralis, Veillonella dispar and Veillonella parvula were most prevalent (100%, all) when described as being present at any amount. Linear correlations between age and several CLR OTUs (Pearson r = − 0.18 to 0.18), of which 82 (31%) achieved statistical significance (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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