Serum and synovial survivin in rheumatoid arthritis: Relation to disease activity and severity

Autor: Eman Baraka, Mounir Serag El Din, Ahmed El Shambky, Nehad A Fouad, Mona Abdullah Abdelkader
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Egyptian Rheumatology and Rehabilitation, Vol 46, Iss 4, Pp 221-228 (2019)
Druh dokumentu: article
ISSN: 1110-161X
2090-3235
DOI: 10.4103/err.err_40_19
Popis: Background Rheumatoid arthritis (RA) is a progressive debilitating autoimmune disease, affecting 1% of the world population, leading to cartilage and bone destruction caused by insufficient apoptosis in the inflamed RA synovium. Survivin is a proto-oncogene biomarker known for its anti-apoptotic and cell cycle-regulating properties. Overexpression of survivin in non-cancerous processes has been linked to inflammation, presumably contributing to the decreased apoptosis in the T cells of the cerebrospinal fluid in multiple sclerosis, in skin lesions of patients with psoriasis and in synovial tissue of patients with RA. Aim of the work The aim of this study is to measure the serum and synovial levels of survivin and clarify their relations to disease activity, functional capacity, and radiographic damage in patients with RA. Patients and methods This study was carried out on 50 patients with RA who had a mean age of 46.4±10.94 years. They were 39 females and 11 males. The control group was of matched age and sex, with a mean age of 46.03±10.53 years and female : male ratio of 23 : 7. All patients were subjected to full history taking, thorough clinical examination, assessment of disease activity by disease activity score 28 activity score, and assessment of functional capacity and disability using Health Assessment Questionnaire. Plain radiographs of both hands of feet were done, scored and graded by Larsen score. Serum survivin from all the studied participants and survivin levels in the synovial fluid aspirated from 18 patients with RA who presented with knee effusion at the time of examination were measured by enzyme-linked immunosorbent assay, using a pair of matched anti bodies (R&D systems, Abingdon, Uk). Results The mean serum survivin level was highly statistically significantly elevated (P
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