Prognostic Value of Serum Cholinesterase Levels for In-Hospital Mortality among Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Autor: Zhixiang Chen, Lei Zha, Guohong Feng, Qian An, Fei Shi, Jingjing Xu, Qiancheng Xu, Huimin Xia, Milan Zhang, Lu Li
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: COPD, Vol 20, Iss 1, Pp 178-185 (2023)
Druh dokumentu: article
ISSN: 1541-2555
1541-2563
15412555
DOI: 10.1080/15412555.2023.2209178
Popis: Cholinesterase (ChE) is associated with the pathogenesis of chronic obstructive pulmonary disease (COPD), including chronic airway inflammation and oxidation/antioxidant imbalance. However, the relationship between serum ChE levels and survival outcomes of patients hospitalized with acute exacerbations of COPD (AECOPD) is unknown. In this retrospective single-center study, we investigated the ability of the serum ChE level to predict in-hospital death in patients hospitalized with AECOPD. The clinicopathological data, including serum ChE levels as well as clinical and biochemical indicators were extracted for 477 patients from the hospital records and analyzed. Our results demonstrated that AECOPD patients with lower serum ChE levels were associated with increased mortality, frequent hospitalization due to acute exacerbations (AE) in the past year, and longer hospital stay. The optimal cutoff value for the serum ChE level was 4323 U/L. The area under the ROC curve (AUC) values for predicting in-hospital mortality based on the serum ChE level was 0.79 (95% confidence interval (CI), 0.72–0.85). Multivariate logistic regression analysis demonstrated that serum ChE level ≤ 4323 U/L (odds ratio (OR) 9.09, 95% CI 3.43–28.3, p
Databáze: Directory of Open Access Journals
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