Geographic differences in pharmacotherapy patterns and outcomes of acute ischemic stroke in China

Autor: Ying Li, Qianhua Ou, Yuxuan Lu, Zhiyuan Shen, Jieyu Li, Zhuangzhuang Zhang, Liwen Tai, Guozhong Li, Huisheng Chen, Guiru Zhang, Lei Zhang, Xuwen Sun, Jinhua Qiu, Yan Wei, Sainan Zhu, Zhaoxia Wang, Weiping Sun, Yining Huang
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: BMC Neurology, Vol 24, Iss 1, Pp 1-10 (2024)
Druh dokumentu: article
ISSN: 1471-2377
DOI: 10.1186/s12883-024-03564-9
Popis: Abstract Background Vast economic and healthcare status discrepancies exist among regions in China, contributing to different treatment patterns. This study was aimed to investigate the current status of pharmacotherapy for acute ischemic stroke (AIS) and outcomes in China and explore the geographic variation in stroke care. Methods This study was a multicenter prospective registry study, which collected the data of patients with AIS from 80 hospitals in 46 cities in 2015–2017 across China. Poor functional outcome defined as a modified Rankin Scale score of 3–6 was assessed at 3 and 12 months. Multivariate logistic regression was used. Results Among 9973 eligible patients, the number of receiving intravenous thrombolysis (IVT), antiplatelet agents, anticoagulants, statin and human urinary kallidinogenase was 429 (4.3%), 9363 (93.9%), 1063 (10.7%), 6828 (74.7%) and 5112 (51.2%), respectively. Multivariable analysis showed IVT use in northeastern was significantly more frequent than in eastern region (OR = 3.17, 95% CI, 2.53–3.99), while the antiplatelets agents use were less frequent (OR = 0.46, 95%CI: 0.38–0.57). The proportions of poor outcomes at 3 and 12 months were 20.7% and 15.8%, respectively. Multivariate analysis showed AIS patients from northeastern and central region had significantly lower risk of poor outcome at month 3 and 12 than those from eastern region (all P
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