Effectiveness and safety of 3 and 5 day courses of artemether–lumefantrine for the treatment of uncomplicated falciparum malaria in an area of emerging artemisinin resistance in Myanmar

Autor:	Kyaw Myo Tun, Atthanee Jeeyapant, Aung Hpone Myint, Zwe Thiha Kyaw, Mehul Dhorda, Mavuto Mukaka, Phaik Yeong Cheah, Mallika Imwong, Thaung Hlaing, Thar Htun Kyaw, Elizabeth A. Ashley, Arjen Dondorp, Nicholas J. White, Nicholas P. J. Day, Frank Smithuis
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Plasmodium falciparum Artemether–lumefantrine Artemisinin resistance kelch13 mutation Myanmar Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216
Zdroj:	Malaria Journal, Vol 17, Iss 1, Pp 1-8 (2018)
Druh dokumentu:	article
ISSN:	1475-2875
DOI:	10.1186/s12936-018-2404-4
Popis:	Abstract Background Artemisinin resistance in Plasmodium falciparum has emerged and spread in Southeast Asia. In areas where resistance is established longer courses of artemisinin-based combination therapy have improved cure rates. Methods The standard 3-day course of artemether–lumefantrine (AL) was compared with an extended 5-day regimen for the treatment of uncomplicated falciparum malaria in Kayin state in South-East Myanmar, an area of emerging artemisinin resistance. Late parasite clearance dynamics were described by microscopy and quantitative ultra-sensitive PCR. Patients were followed up for 42 days. Results Of 154 patients recruited (105 adults and 49 children
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/47d761c22719496893d101dda86b38a2 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.