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Maduka Donatus Ughasoro,1 Gilbert Nwadiaka Adimorah,1 Ndubuisi Kennedy Chukwudi,2 Ifeyinwa Dorothy Nnakenyi,3 Kenechukwu Kaosisochukwu Iloh,1 Charles Ejike Udemba41Department of Paediatrics, University of Nigeria Enugu Campus, Enugu, Nigeria; 2Department of Paediatrics, Federal Medical Centre, Umuahia, Abia State, Nigeria; 3Department of Chemical Pathology, University of Nigeria Enugu Campus, Enugu, Nigeria; 4Department of Paediatrics, University of Nigeria Teaching Hospital, Enugu, NigeriaBackground: Phototherapy is paramount in the management of high total serum bilirubin (TSB). Whether its effectiveness can be improved with ursodeoxycholic acid (UDCA) has not been evaluated among newborns of African descent.Methods: A double-blind-controlled study was used to evaluate the effect of UDCA on the management of high TSB in neonates. Recruited neonates were categorized into the experimental group (given UDCA plus phototherapy) and the control group (phototherapy and plain syrup), and their TSB and conjugated bilirubin levels were measured. The data were analyzed using SPSS version 20. Statistical significance was set at a p-value of |
