Proliferative and inflammatory factors in the vitreous of patients with proliferative diabetic retinopathy
| Autor: | V V Chernykh, E V Varvarinsky, E V Smirnov, D V Chernykh, Alexander N Trunov |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Cup to disc ratio
disc area glaucoma probability score moorfields regression analysis optical coherence tomography Antioxidant supplementation diabetes mellitus free oxygen radicals test nonproliferative diabetic retinopathy reactive oxygen species In vivo confocal microscopy keratocyte density prostaglandin analogues Chronic glaucoma patients economic burden socioeconomic profile Bevacizumab macular edema refractory retinal vein occlusion triamcinolone acetonide Corneal thickness menstrual cycle pachymetry refractive surgery Cytokines diabetic retinopathy pigment epithelium-derived factor vascular endothelial growth factor Ophthalmology RE1-994 |
| Zdroj: | Indian Journal of Ophthalmology, Vol 63, Iss 1, Pp 33-36 (2015) |
| Druh dokumentu: | article |
| ISSN: | 0301-4738 1998-3689 |
| DOI: | 10.4103/0301-4738.151464 |
| Popis: | Purpose: The purpose was to measure the concentrations of various cytokines and growth factors (including vascular endothelial growth factor [VEGF] and pigment epithelium-derived factor [PEDF]) in the vitreous of patients with proliferative diabetic retinopathy (PDR) and to investigate interaction between inflammatory and proliferative factors in the genesis of PDR. Materials and Methods : Vitreous samples from 32 eyes with PDR and 25 eyes without diabetes mellitus and signs of DR (control) were collected. Vitreous concentrations of VEGF, PEDF, monocyte chemotactic protein-1 (MCP-1), interleukin-4 (IL-4), IL-6, IL-8, IL-10, IL-17A, and secretory immunoglobulin A (sIgA) were simultaneously measured using enzyme-linked immunoassay. Results : Vitreous levels of VEGF, PEDF, IL-17A, IL-6, IL-8, IL-4, and sIgA were significantly (Π < 0.05) higher in eyes with PDR compared to control. The concentration of VEGF was more than 17-times higher than in control, and the concentration of PEDF was not changed oppositely and was also higher (1.45-times) compared to control, that may indicate disturbances of compensatory mechanisms in angiogenesis regulation in PDR. Significant (Π < 0.05) positive correlations were observed between vitreous concentrations of VEGF and IL-17ΐ (r = 0.45), VEGF and IL-8 (r = 0.48), VEGF and IL-4 (r = 0.51), PEDF and IL-17ΐ (r = 0.48), PEDF and IL-8 (r = 0.59), MCP-1 and PEDF (r = 0.72), MCP-1 and IL-8 (r0 = 0.45), IL-4 and IL-17ΐ (r = 0.65), IL-4 and IL-8 (r = 0.71), IL-8 and IL-17ΐ (r = 0.59). Conclusions: Significantly raised levels of inflammatory and proliferative factors and numerous positive correlations between them may demonstrate a significant role of activation of vascular proliferation and local inflammation in the pathogenesis of PDR. |
| Databáze: | Directory of Open Access Journals |
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