Immunological studies and in vitro schistosomicide action of new imidazolidine derivatives
| Autor: | Neves JKAL, Sarinho S, de Melo CML, Pereira VRA, de Lima MCA, Pitta IR, Albuquerque MCPA, Galdino SL |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 17, Iss 3, Pp 277-286 (2011) |
| Druh dokumentu: | article |
| ISSN: | 1678-9199 22206450 |
| DOI: | 10.1590/S1678-91992011000300007 |
| Popis: | Schistosomiasis is a major public health problem with 207 million people infected and more than 779 million at risk. The drug of choice for treating schistosomiasis is praziquantel (PZQ); however, it is inefficient against immature forms of schistosomes. The aim of this study was to test new imidazolidine derivatives LPSF/PT09 and LPSF/PT10 against adult Schistosoma mansoni worms. IC50, cytotoxicity, immune response and cell viability assays were also available for these imidazolidines. Different concentrations of imidazolidine, from 32 to 320 ¼M, promoted motor abnormalities in breeding and unpaired worms, and death in 24 hours at higher concentrations. Although LPSF/PT09 and LPSF/PT10 did not affect IFN-³ and IL-10 production, they induced nitric oxide production and showed a similar behavior to praziquantel on cell death test. Thus, these new imidazolidine derivatives should undergo further study to develop schistosomiasis drugs. |
| Databáze: | Directory of Open Access Journals |
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