PHLDA3 impedes somatic cell reprogramming by activating Akt-GSK3β pathway

Autor:	Mengran Qiao, Mian Wu, Ronghua Shi, Wanglai Hu
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	Medicine Science
Zdroj:	Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-017-02982-9
Popis:	Abstract Reprogramming of adult somatic cells into induced pluripotent stem cells holds great promise in clinical therapy. Increasing evidences have shown that p53 and its target genes play important roles in somatic cell reprogramming. In this study, we report that PHLDA3, a p53 target gene, functions as a blockage of iPSCs generation by activating the Akt-GSK3β pathway. Furthermore, PHLDA3 is found to be transcriptionally regulated by Oct4. These findings reveal that PHLDA3 acts as a new member of the regulatory network of somatic cell reprogramming.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/46b8c69175644bd1a57a0477d1d5901d Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.