A clinical case of primary membranous glomerulonephritis with nephrotic syndrome and resistance to standard treatment
| Autor: | L.D. Denova, I.V. Krasiuk |
|---|---|
| Jazyk: | English<br />Ukrainian |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Počki, Vol 12, Iss 4, Pp 211-220 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2307-1257 2307-1265 |
| DOI: | 10.22141/2307-1257.12.4.2023.431 |
| Popis: | The incidence of primary membranous glomerulonephritis is 1 case per 100,000 each year (75–80 %), with a male-to-female ratio of 2 : 1. It is the cause of idiopathic nephrotic syndrome in more than 20 % of cases (over 40 % in people aged 60 and older). The problem of membranous glomerulonephritis consists in a difficult differential diagnostic search and frequent cases of resistance to treatment. Resistance to treatment may develop in 10–20 % of patients, resulting in the end-stage renal disease requiring renal replacement therapy (dialysis or kidney transplantation). Our work presents the results of clinical observation of a patient with primary membranous glomerulonephritis, nephrotic syndrome and resistance to standard treatment. This patient had a positive dynamics of clinical-laboratory-instrumental indicators and an improvement in the quality of life against the background of taking rituximab. |
| Databáze: | Directory of Open Access Journals |
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