| Autor: |
Hritcu L., Stefan M., Misaila Costica, Ciobica A., Dumitru Gabriela |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
Archives of Biological Sciences, Vol 63, Iss 1, Pp 99-105 (2011) |
| Druh dokumentu: |
article |
| ISSN: |
0354-4664 |
| DOI: |
10.2298/ABS1101099H |
| Popis: |
The effects of lipopolysaccharide (LPS) on immune modulation in rats subjected to a right-unilateral lesion of the substantia nigra neurons by means of 6-hydroxydopamine (6-OHDA), were investigated. LPS administration (250 μg) significantly decreases the total number of leukocytes and erythrocytes, as well as the hemoglobin level in the 6-OHDAlesioned rats. In addition, LPS administration was also associated with an increase, relative to control, in the erythrocyte indexes and the phagocytosis by neutrophils, and in blastic transformation of T lymphocytes. The obtained data indicated that LPS exposure might represent a risk factor for the development of the immunological changes associated with Parkinson’s disease. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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