| Autor: |
Radek Sindelka, Ravindra Naraine, Pavel Abaffy, Daniel Zucha, Daniel Kraus, Jiri Netusil, Karel Smetana, Lukas Lacina, Berwini Beduya Endaya, Jiri Neuzil, Martin Psenicka, Mikael Kubista |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Genome Biology, Vol 25, Iss 1, Pp 1-28 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1474-760X |
| DOI: |
10.1186/s13059-024-03396-3 |
| Popis: |
Abstract Background Embryos are regeneration and wound healing masters. They rapidly close wounds and scarlessly remodel and regenerate injured tissue. Regeneration has been extensively studied in many animal models using new tools such as single-cell analysis. However, until now, they have been based primarily on experiments assessing from 1 day post injury. Results In this paper, we reveal that critical steps initiating regeneration occur within hours after injury. We discovered the regeneration initiating cells (RICs) using single-cell and spatial transcriptomics of the regenerating Xenopus laevis tail. RICs are formed transiently from the basal epidermal cells, and their expression signature suggests they are important for modifying the surrounding extracellular matrix thus regulating development. The absence or deregulation of RICs leads to excessive extracellular matrix deposition and defective regeneration. Conclusion RICs represent a newly discovered transient cell state involved in the initiation of the regeneration process. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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