Sex differences in hearing impairment due to diet-induced obesity in CBA/Ca mice

Autor:	Soo Jeong Kim, Akanksha Gajbhiye, Ah-Ra Lyu, Tae Hwan Kim, Sun-Ae Shin, Hyuk Chan Kwon, Yong-Ho Park, Min Jung Park
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Hearing loss HFD-induced obesity Auditory brainstem response (ABR) Distortion product otoacoustic emissions (DPOAE) Wave 1 amplitude CtBP2 Medicine Physiology QP1-981
Zdroj:	Biology of Sex Differences, Vol 14, Iss 1, Pp 1-17 (2023)
Druh dokumentu:	article
ISSN:	2042-6410
DOI:	10.1186/s13293-023-00493-z
Popis:	Highlights Females are protected against HFD-induced metabolic alterations and hearing impairment. Sex differences were seen in the ABR wave 1 amplitude, which correlated with loss of hair-cell ribbon synapses (CtBP2). The serum adiponectin concentration was significantly higher in female compared to male mice, and the cochlear adiponectin levels were elevated by HFD in females, but not male mice. Cochlear and liver AdipoR1 expression evidenced significant sex differences in CBA/Ca mice. The core stress granule component, G3BP1, was induced by HFD in the cochleae of male and female mice. Significant sex differences were found in cochlear blood flow and IL-1β concentration.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/43c31626725d46a4894eb2ed6603b99b Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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