Class II PI3Ks at the Intersection between Signal Transduction and Membrane Trafficking

Autor:	Jean Piero Margaria, Edoardo Ratto, Luca Gozzelino, Huayi Li, Emilio Hirsch
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	PIK3C2A PIK3C2B PIK3C2G PI3K-C2α PI3K-C2β PI3K-C2γ PI3K68D piki-1 membrane trafficking signal transduction Microbiology QR1-502
Zdroj:	Biomolecules, Vol 9, Iss 3, p 104 (2019)
Druh dokumentu:	article
ISSN:	2218-273X
DOI:	10.3390/biom9030104
Popis:	Phosphorylation of inositol phospholipids by the family of phosphoinositide 3-kinases (PI3Ks) is crucial in controlling membrane lipid composition and regulating a wide range of intracellular processes, which include signal transduction and vesicular trafficking. In spite of the extensive knowledge on class I PI3Ks, recent advances in the study of the three class II PI3Ks (PIK3C2A, PIK3C2B and PIK3C2G) reveal their distinct and non-overlapping cellular roles and localizations. By finely tuning membrane lipid composition in time and space among different cellular compartments, this class of enzymes controls many cellular processes, such as proliferation, survival and migration. This review focuses on the recent developments regarding the coordination of membrane trafficking and intracellular signaling of class II PI3Ks through the confined phosphorylation of inositol phospholipids.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/c435803c03bb42c7a78a77921f40ba2c Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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