Polyphenolic characterization and evaluation of multimode antioxidant, cytotoxic, biocompatibility and antimicrobial potential of selected ethno-medicinal plant extracts

Autor: Sania Atta, Durdana Waseem, Iffat Naz, Faisal Rasheed, Abdul Rehman Phull, Tofeeq Ur-Rehman, Nadeem Irshad, Parveen Amna, Humaira Fatima
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Arabian Journal of Chemistry, Vol 16, Iss 2, Pp 104474- (2023)
Druh dokumentu: article
ISSN: 1878-5352
DOI: 10.1016/j.arabjc.2022.104474
Popis: Introduction: Scientific evidence about biological profile of natural products can support their traditional uses. The current work was aimed to assess phytochemical and biological profile of nine medicinal plants collected from Herbalists. Methods: Extracts prepared in different solvents were subjected to phytochemical, antioxidant, enzyme inhibitory, cytotoxic, and antimicrobial activities. Reverse phase-high performance liquid chromatography (RP-HPLC) analysis was performed for the quantification of polyphenols. Results: Results showed methanol extract (M) being potent as compared to others. Gentian lutea M showed maximum extract recovery (15.00 ± 0.11 % w/w) and TFC (30.82 ± 0.21 μg QE/mg extract). Nigella sativa M displayed highest TPC (44.99 ± 0.43 μg GAE/mg extract) and TAC (334.72 ± 0.35 μg AAE/ mg extract). Results showed noteworthy quantities of vanillic acid, rutin, kaempferol, emodin in ethyl acetate (EA) and methanol (M) extracts of plants assessed by RP-HPLC. Gentisic acid was highest (11.75 µg/mg extract) in T. arjuna M extract. Similarly, maximum %FRSA (82.28 ± 0.03 %) and TRP (160.40 ± 0.38 μg AAE/ mg extract) were depicted by Terminalia chebula and Chamomilla recutita, respectively. Moreover, Mentha longifolia and G. lutea M demonstrated noteworthy (p
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