A macrophage-specific lncRNA regulates apoptosis and atherosclerosis by tethering HuR in the nucleus

Autor: Viorel Simion, Haoyang Zhou, Stefan Haemmig, Jacob B. Pierce, Shanelle Mendes, Yevgenia Tesmenitsky, Daniel Pérez-Cremades, James F. Lee, Alex F. Chen, Nicoletta Ronda, Bianca Papotti, Jarrod A. Marto, Mark W. Feinberg
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-19664-2
Popis: Long non coding RNA molecules have been implicated in the immunopathology of a range of inflammatory pathologies. Here the authors show lncRNA MAARS regulates apoptosis via interaction with HuR in the context of atherosclerosis.
Databáze: Directory of Open Access Journals